Protein Spotlight 206

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206 - Bleeding Disorders

more than 65 years old, and the use of antiplatelet agents is vastly more common than that. Patients with inherited bleeding disorders will likely present to the emergency department (ED) for treatment of abnormal bleeding at some point during their lifetime, and ED visits for bleeding in patients who are taking antithrombotic agents are not uncommon. The clinician must be familiar with these d...

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We report a method of photo-cross-linking proteins in mammalian cells, which is based on site-specific incorporation of a photoreactive amino acid, p-benzoyl-L-phenylalanine (pBpa), through the use of an expanded genetic code. To analyze the cell signaling interactions involving the adaptor protein Grb2, pBpa was incorporated in its Src homology 2 (SH2) domain. The human GRB2 gene with an amber...

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Aug08 p195-206 CME

leg ulcers. Prevalence data describing the etiology of at least one foot ulcer among the 20.8 million Americans who have diabetes has been estimated to be between 12.7%-15%. Further, in the United States, approximately 60% of all lower extremity amputations occur among persons with diabetes; of these lower extremity amputations, a foot ulcer preceded the resulting amputation by 85%. Continued o...

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ژورنال

عنوان ژورنال: EMBnet.journal

سال: 2019

ISSN: 2226-6089

DOI: 10.14806/ej.24.0.923